Universal Pipette Tips

Low Binding Pipette Tip

Low Binding Pipette Tips are designed to minimize sample loss and ensure accurate and precise sample dispensing. These tips are ideal for applications that require minimal retention of samples, such as protein assays or DNA/RNA amplification.

Features and Benefits:

Low binding design: The low binding surface of these tips minimizes sample loss and ensures accurate and precise sample dispensing.
Compatible with most pipettes: These tips are designed to fit most pipettes available in the market, ensuring compatibility with your existing equipment.
Clear graduation marks: The clear graduation marks on the tips make it easy to identify the volume dispensed, reducing the risk of errors.
DNase/RNase-free and non-pyrogenic: These tips are free from DNase, RNase, and pyrogens, making them suitable for use in molecular biology applications.

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Specifications

Volume range:	10ul，200ul，1000ul，1250ul
Material:	USP Class VI medical grade Polypropylene (PP)
Sterilization:	E-beam radiation for sterilized tips
DNase/RNase-free and non-pyrogenic

Low binding pipette tips are specialized laboratory consumables designed to minimize the binding of biomolecules, such as DNA, RNA, proteins, enzymes, and other sensitive molecules, to the surface of the pipette tip during pipetting. They are essential for applications where sample recovery and purity are critical, as they help reduce sample loss and improve the accuracy of experiments.
Key features of low binding pipette tips include:
Low Retention Materials: These tips are typically made from plastics like polypropylene, which are treated or manufactured to have a low surface energy, reducing the attraction of biomolecules to the tip's surface.
Sterilization: Low binding tips are often sterilized using gamma irradiation or autoclaving to maintain sample purity and prevent contamination.
Minimal Dead Volume: These tips are designed to minimize dead volume, ensuring that the majority of the sample is expelled from the tip during dispensing.
Ultra-Hydrophobic Coating: Some low binding tips have an ultra-hydrophobic coating that repels aqueous solutions, further reducing the risk of sample retention.
Applications of low binding pipette tips:
Molecular Biology: These tips are crucial in molecular biology techniques such as PCR, DNA sequencing, and DNA/RNA purification, where maintaining sample purity and preventing cross-contamination are essential.
Protein and Enzyme Work: Low binding tips are used when handling proteins and enzymes to prevent sample loss and ensure accurate quantification and manipulation.
Cell Culture: In cell culture work, they help reduce sample loss and maintain cell viability when transferring cells or cell culture media.
Drug Discovery and Pharmaceutical Research: Low binding tips are used for precise dispensing of small volumes of expensive drug compounds, ensuring efficient and accurate assays.
Microplate Work: In high-throughput screening, low binding tips are employed for sample transfer and reagent addition to microplates, improving assay reliability.
Sample Dilution and Preparation: They are used for accurate sample dilutions and preparations, ensuring consistency in research and clinical diagnostics.
Choosing the right low binding tip is essential for specific applications and experiments. Some tips are tailored for DNA or RNA work, while others are designed for general use. Proper pipetting techniques are also important to maximize the benefits of low binding tips and prevent sample loss or contamination.

Applications
- Protein assays
- DNA/RNA amplification
- PCR & qPCR
- Sequencing
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About

Zhejiang ZSup Medical Technology Co., Ltd.

Zhejiang ZSup Medical Technology Co., Ltd was established in 2018, Is a Low Binding Pipette Tip Manufacturers and Low Binding Pipette Tip Suppliers, by expert Teams of mold manufacturing, polymer materials, biomedicine, and IOT. We produce high-quality laboratory consumables in GMP qualified 100,000-level cleanliness level purification workshop. We also undertake manufacture of high-precision injection mold, customized bio supplies. We strive to provide one-stop solutions to our customers.
Manufacture of high-precision mold: Technical team own excellent experiences in producing of high-precision molds for bio supplies, particularly for thin-walled, multi-cavity, high-speed injection molds.
Manufacture of injection molding products: Top level production of laboratory supplies by world class QC and QA management, including
· General consumables: centrifuge tubes, tips, PCR, cell culture products, etc.;
· Customized consumables: all kinds of automated special biological experiment consumables;
· OEM customization: sharing equipment, molds, production lines, and available for OEM manufacture.
We offer a great balance of quality and affordability, while maintaining high-quality standards by leveraging economies of scale, optimizing production processes, and sourcing materials.

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Industry Knowledge Extension

How does the Low Binding Pipette Tip reduce the adhesion between the sample and the pipe wall and improve the recovery rate?

The Low Binding Pipette Tip uses a series of design features and material selections to reduce sample adhesion to the pipe wall, thereby increasing recovery rates. Here are some key measures:
Inner surface design: The inner surface of the Low Binding Pipette Tip is designed to be very smooth, reducing the contact area between the sample and the tube wall, thereby reducing the possibility of adhesion. This design allows the sample to flow more easily and reduces residue on the tube wall.
Special coating: These tips are often coated with a special anti-stick coating, such as polytetrafluoroethylene (PTFE) or polyethylene (PE). These coatings have extremely low surface energy, making it difficult for sample molecules to adhere to the tube wall. By reducing the interaction force between the sample and the tube wall, these coatings significantly improve sample recovery.
Material selection: The materials used in Low Binding Pipette Tip are usually high-purity, low-adsorption polymers. These materials are inherently less susceptible to chemical or physical interactions with sample molecules, reducing the potential for adhesion.
Control the gas speed: When using Low Binding Pipette Tip for pneumatic transportation, proper control of the gas transportation speed is also the key to reducing adhesion. Gas velocities that are too fast may increase the likelihood of sticking, while gas velocities that are too slow may cause the sample to sink. Therefore, reasonable adjustment of the gas velocity according to the adhesion properties of the sample and the diameter of the pipe can help reduce the occurrence of adhesion phenomena.
Regular cleaning and maintenance: Regular cleaning and maintenance of the Low Binding Pipette Tip is also the key to ensuring its stable performance. Cleaning removes residue and contaminants from the tube walls, preventing them from adhering to the sample. At the same time, timely replacement of worn or damaged suction heads can also ensure the stability of the recovery rate.
To sum up, the Low Binding Pipette Tip effectively reduces the adhesion between the sample and the pipe wall by optimizing the inner surface design, using special coatings, selecting appropriate materials, controlling gas speed, and regular cleaning and maintenance, thereby reducing the adhesion between the sample and the pipe wall. Improved recycling rates. These characteristics make the Low Binding Pipette Tip widely applicable in experiments requiring high recovery rates.

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